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Contraindicated (one)pentobarbital will minimize the extent or result of cariprazine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. CYP3A4 is to blame for the formation and elimination of cariprazine's Energetic metabolites.pentobarbital raises effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Ca